期刊论文

Clinical study of Adefovir Dipivoxil combined with Oxymatrine in treating patients with HBeAg-positive chronic hepatitis B

中文

中国中西医结合消化杂志

1671-038X

2012

20

4

170-173

10.3969/j.issn.1671-038X.2012.04.010

本校为第一机构

[目的]比较阿德福韦酯联合苦参素与阿德福韦酯单药治疗HBeAg阳性慢性乙型肝炎(CHB)患者的临床疗效和安全性.[方法]将124例患者随机分为2组,各62例,治疗组给予阿德福韦酯胶囊10mg/d和苦参素胶囊0.2 g/次,3次/d,口服52周；对照组给予阿德福韦酯胶囊10mg/d,52周.观察2组治疗前后患者HBV DNA阴转率、HBeAg阴转率和HBeAg血清学转换率及丙氨酸氨基转移酶(ALT)复常率.[结果]治疗组和对照组HBV DNA阴转率分别为48.14％和40.38％(P＞0.05),ALT复常率为72.46％和76.82％ (P＞0.05),HBeAg阴转率为40.74％和26.92％(P＜0.05),HBeAg血清学转换率为35.18％和19.23％ (P＜0.05).[结论]阿德福韦酯联合苦参素治疗...

[Objective]To evaluate the efficacy and safety of Adefovir Dipivoxil combined with Oxymatrine in HBeAg-positive chronic hepatitis B（CHB） patients. [Methods]One hundred and twenty-four CHB patients were randomly divided into 2 groups：Adefovir Dipivoxil combined with Oxymatrine group,and Adefovir Dipivoxil group.Some indices were observed including HBV DNA,HBeAg,serum of HBeAg as well as ALT before and after treatment. [Results]At 52 weeks＇ treatment,HBV DNA negative response rate was 48.14% and 40.38% respectively in the two groups（P0.05） ...