期刊论文

Correlation between macrophage inhibitory cytokine-1 , neuropeptide Y levels and anorexia in patients with colorectal cancer

中文

中国中西医结合消化杂志

1671-038X

2013

21

6

287-289

10.3969/j.issn.1671-038X.2013.06.03

湖南省科技计划项目（No:2009sk3068）；

本校为第一机构

[目的]探讨肠癌患者血清巨噬细胞抑制因子-1(MIC-1)、神经肽Y(NPY)的表达及其与患者食欲减退的相关性.[方法]采用ELISA法测定34例晚期肠癌患者3个月前后血清MIC-1、NPY的表达,并进行食欲评分和体质指数计算.[结果]研究前34例患者MIC1、NPY水平分别为(947.55±82.83)、(118.59±8.55) pg/ml；随访3个月后有6例患者死亡,余28例患者MIC-1水平升高为(1195.09±122.32) pg/ml,NPY水平下降至(99.20±7.33)pg/ml;前、后比较均差异有统计学意义(P＜0.01).3个月后食欲评分及体质指数均较研究前下降；食欲评分及体质指数与血清MIC-1呈显著负相关,与NPY呈显著正相关(均P＜0.01).[结论]晚期肠癌患者血清MIC-...

[-Objective]To investigate the expression of MIC-1 in serum samples of colorectal cancer pa- tients and the correlation with the loss of appetite, [Methods]The expression of MIC-1 and NPY was de- tected by using the ELISA method in 34 advanced colorectal cancer patients＇ serum samples before and af- ter 3 months. And the appetite ratings and body mass index were calculated. [,Results]The expression of MIC-1 and NPY in 34 cases before the study was （947.55 ± 82.83）, （118. 59 ± 8.55） pg/ml respective- ly. After 3 months, 6 patients died. T...