期刊论文

The study on angiogenic from gastric precancerous lesions effect through Ecan Jianwei recipe regulating MMP-2＇s expression

中文

中国中西医结合消化杂志

1671-038X

2017

25

3

210-215

10.3969/j.issn.1671-038X.2017.03.13

湖南省科技厅社会发展支撑计划（No:2014SK3058）；

本校为第一机构

[目的]探讨莪蚕健胃方对胃癌前病变大鼠MMP-2蛋白及其mRNA对血管生成的影响.[方法]实验大鼠分为正常组5只,造模组55只.制作胃癌前病变模型24周并抽检5只确保成功后,将剩余模型大鼠随机分为模型组,维甲酸组和中药高、中、低剂量组,每组10只.给药16周后处死取材.进行胃组织病理检测,MVD计数,和MMP-2蛋白及mRNA的检测.[结果]与正常组比较,造模组的MVD和MMP-2蛋白及其mRNA均过度表达(F＜0.05),并随异型增生级别的升高而增强.MMP-2蛋白与MVD正相关(r=0.560,P＜0.05),MMP-2 mRNA与MVD无相关性(r=0.297,P＞0.05).在MVD、MMP-2蛋白及其mRNA的表达方面:与模型组相比,大部分治疗组能抑制其过度表达(P＜0.0...

[Objective]To investigate the effects on angiogenesis from Ecan Jianwei recipe of gastric precancerous lesions rats'MMP-2's protein and mRNA.[Methods]The experimental rats were divided into normal group with 5 rats,the module group with 55 rats.And sampled 5 rats to ensure the success of making gastric precancerous lesion model for 24 weeks,then divided the rest of the model rats randomly into the model group,the retinoic acid treatment group,the high dose of Chinese medicine、medium dose、low dose treatment groups with 10 each.Administering fo...