期刊论文

中文

中国中西医结合消化杂志

1671-038X

2023

31

04

285-292

10.3969/j.issn.1671-038X.2023.04.09

No:81874466:国家自然科学基金 No:2021JJ30531:湖南省自然科学基金面上项目 No:20A378:湖南省教育厅科学研究项目

本校为第一机构

目的:研究溃结宁膏对HT-29细胞炎症模型的影响并基于microRNA-155(miR-155)/酪氨酸蛋白激酶(janus kinase,JAK)/信号转导及转录激活因子(signal transducer and a...展开更多 目的:研究溃结宁膏对HT-29细胞炎症模型的影响并基于microRNA-155(miR-155)/酪氨酸蛋白激酶(janus kinase,JAK)/信号转导及转录激活因子(signal transducer and activator of transcription,STAT)通路探讨其机制。方法:体外培养HT-29细胞建立溃疡性结肠炎炎症模型,分为空白对照组、炎症模型组、模型对照组、miR-155 mimics组、miR-155 inhibitor组、穴位敷贴组、柳氮磺吡啶(SASP)组。乳酸脱氢酶法检测细胞损伤,ELISA检测细...

Objective:To investigate the effect of Kuijiening Plaster on the inflammation model of HT-29 cells and explore the mechanism based on microRNA-155(miR-155)/janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway.Methods:HT-29 cells were cultured ...MORE Objective:To investigate the effect of Kuijiening Plaster on the inflammation model of HT-29 cells and explore the mechanism based on microRNA-155(miR-155)/janus kinase(JAK)/signal transducer and activator of transcription(STAT)pathway.Methods:HT-29 cells were cultured in vitro to establish an inflammatory model of ulcer...