期刊论文

Improving effect of Jiarong Tablets on the morphological structure and function of the testis in rats with late-onset hypogonadism

中文

中华男科学杂志

1009-3591

2020

26

03

237-241

10.13263/j.cnki.nja.2020.03.009

国家自然科学基金（81202706、81673984）； 湖南省自然科学基金（2018JJ3402）； 长沙市杰出创新青年人才项目（kq1802015）； 湖南省***卫生人才225工程医学学科骨干人才培养对象（湘卫函[2019]196号）； 湖南创新型省份建设专项经费资助-“湖湘青年英才”支持计划（2019RS2041）； 中华中医药学会“青年人才托举工程”（2019-QNRC2-C07）~~；

本校为其他机构

目的:探讨佳蓉片对迟发性性腺功能减退症(LOH)大鼠睾丸形态结构与功能改善作用. 方法:18月龄雄性SD大鼠随机分为模型组、佳蓉片组,2月龄雄性SD大鼠设为正常对照组,佳蓉片组给予0.375 g/(kg·d)体重剂量的佳蓉片灌胃,每天1次;正常对照组和模型组给予相同体积的蒸馏水灌胃,连续给药28 d.实验结束后对所有大鼠称重,取血清检测睾酮(T)含量,睾丸组织进行病理学及电镜检测. 结果:与正常对照组相比,佳蓉片组、模型组大鼠睾丸系数显著降低(P均＜0.05),模型组大鼠血清T水平:[(3.40±0.06)vs(5.88±0.46) ng/ml]显著降低(P＜0.05);与模型组相比,佳蓉片组体重和睾丸系数差异无统计学意义(P＞0.05),血清T[(4...

Objective: To investigate the effect of Jiarong Tablets (JRT) on the testicular morphology and function of rats with late-onset hypogonadism (LOH). Methods: LOH models were established in 8 eighteen-month-old male SD rats,treated intragastrically with distilled water (the model control group,n = 4) or JRT at 0.375 g/kg/d,qd (the JRT group,n = 4),and another 5 two-month-old normal male SD rats were also given distilled water by gavage (normal control group),all for 28 days. Then all the rats were weighed and sacrificed for measurement of the ser...