期刊论文

Xiongcan Yishen Prescription upregulates the expressions of eNOS and cGMP in the penile tissue of ED rats with liver depression and kidney deficiency

中文

中华男科学杂志

1009-3591

2020

26

02

167-173

10.13263/j.cnki.nja.2020.02.013

国家自然科学基金（81202706,81673984,81774324）； 湖南省自然科学基金（2018JJ3402）； 湖南省教育厅优秀青年项目（16B200）； 长沙市杰出创新青年人才项目（kq1802015）~~；

本校为第一机构

目的:探讨雄蚕益肾方对肝郁肾虚ED大鼠阴茎eNOS、cGMP表达的影响. 方法:50只8周龄SPF级雄性SD大鼠随机分为空白组,模型组,西药对照组,中成药对照组和雄蚕益肾方低、中、高剂量组,从50只雄性SD大鼠中随机抽取10只为空白组大鼠,其余大鼠均采用氢化可的松注射液肌注加束缚四肢复合造模方法连续14 d诱发肝郁肾虚ED模型.造模成功后,每组5只,西药对照组给予他达拉非片溶液0.52 mg,/(kg·d),中成药对照组给予疏肝益阳胶囊溶液0.3 125 g/(kg·d),雄蚕益肾方低、中、高剂量为10.4、20.8、41.6 g/(kg·d),空白组、模型组给予等体积蒸馏水,各组每日均早、晚各灌胃一次,连续28 d.造模前、造模完成后、给药28...

Objective: To investigate the effect of Xiongcan Yishen Prescription (XYP) on the expressions of eNOS and cGMP in the penile tissue of ED rats with liver depression and kidney deficiency (LDKD). Methods: The model of ED-LDKD was established in 30 eight-week-old SPF-class male SD rats by injecting hydrocortisone intramuscularly and binding the limbs for 14 days, and another 10 rats were taken as blank controls. Then, the model rats were randomized into six groups of equal number and treated intragastrically with distilled water (model control), ...