Objective: To observe the clinical effects of treating chronic persistent UC with the Xianyu decoction. Methods: 68 patients with chronic persistent UC were randomly divided into treatment group (35cases) and control group (33cases). Mesalazine were taken by oral in two groups, and the Xianyu decoction was given additionally in treatment group. Each group treatment time was three months. Results: The symptoms and intestinal mucosal image in treatment group can be significantly improved, and the curative effect in treatment group is bette...