期刊论文

Qin, L

英文

Biomedicine & Pharmacotherapy

0753-3322

2023

164

114981

10.1016/j.biopha.2023.114981

National Natural Sciences Foundation of China; National Science Fund of Hunan Province; Youth Project of Natural Science Foundation of Hunan Province [82274159, 81973668, 81774130]; Key Project of the Educational Department of Hunan Province [2022JJ80088]; Ministry of Traditional Chinese Medicine Powder and Innovative Drug Research in Hunan Province [2023JJ40485]; Scientific Research Project of Changsha Science and Technology Bureau [20A375, 21A0226]; Key Project of Hunan Provincial Health Commission [21PTKF1004]; Outstanding Youth Project of Educational Department of Hunan Province [kq2004060]; Graduate Research innovation project of Hunan University of Chinese Medicine [202213055529]; Hunan Provincial College Student Innovation and Entrepreneurship Training Program [22B0355]; First-Class Discipline of Pharmaceutical Science of Hunan [2022CX76]; [S202110541072]

本校为第一且通讯机构

Lipid metabolism disorders are pivotal in the development of various lipid-related diseases, such as obesity, atherosclerosis, non-alcoholic fatty liver disease, type 2 diabetes, and cancer. Celastrol, a bioactive compound extracted from the Chinese herb Tripterygium wilfordii Hook F, has recently demonstrated potent lipid-regulating abilities and promising therapeutic effects for lipid-related diseases. There is substantial evidence indicating that celastrol can ameliorate lipid metabolism disorders by regulating lipid profiles and related metabolic processes, including lipid synthesis, catab...