期刊论文

Research of the effects of glucose regulated protein 78 on chronic diabetic complications

中文

湖南中医药大学学报

1674-070X

2014

34

1

53-56

10.3969/j.issn.1674-070X.2014.01.016.053.04

81273753:国家自然科学基金 12JJ2048:湖南省自然科学基金 CX2013B321:湖南省研究生科研创新项目

本校为第一机构

葡萄糖调节蛋白78(GRP78)是存在于内质网上主要的分子伴侣蛋白,也是内质网应激的标志性分子之一.近年来实验研究证实GRP78与糖尿病慢性并发症的发生、发展密切相关；靶向GRP78的研究也为糖尿病慢性并发症的治疗提供了新思路和新方法.

Glucose regulated protein 78 （GRP78） is a main molecular chaperone protein in the endoplasmic reticulum and one of the marker molecules of endoplasmic reticulum stress.In recent years,experimental studies are confirmed that GRP78 is correlated with the occurrence and the development of chronic complications of diabetes.The studies of targeted GRP78 are provided new approaches for ...