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Effects of nourishing qi, activating blood circulation, and inducing resuscitation on nerve cell pyroptosis after cerebral ischemia-reperfusion

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成果类型:
期刊论文
作者:
Liu, Lin-Quan;Huang, Xiao-Ping;Cai, Ya-Hong;She, Yan;Deng, Chang-Qing
作者机构:
[Liu, Lin-Quan; Deng, Chang-Qing] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Hunan, Peoples R China.
[Huang, Xiao-Ping] Hunan Univ Chinese Med, Key Lab Hunan Prov Integrated Tradit Chinese & Wes, Changsha, Hunan, Peoples R China.
[Cai, Ya-Hong] Hunan Univ Tradit Chinese Med, Chron Dis Management Dept, Affiliated Hosp 1, Changsha, Hunan, Peoples R China.
[She, Yan] Hunan Univ Chinese Med, Med Coll, Lab Vasc Biol, Changsha, Hunan, Peoples R China.
语种:
英文
关键词:
BAP;cerebral ischemia-reperfusion;Nrf2;HO-1 signaling pathway;pyroptosis
期刊:
Quality Assurance and Safety of Crops & Foods
ISSN:
1757-8361
年:
2023
卷:
15
期:
1
页码:
193-206
基金类别:
Open Fund for Integrated Traditional Chinese and Western Medicine [2020ZXYJH33]; Key project of the Hunan Education Department [19A381]; domestic first -class cultivation discipline project of Integrated Traditional Chinese and Western Medicine in Hunan Province [2021ZXYJH06]; Natural Science Foundation of Hunan Province [2020JJ4474]
机构署名:
本校为其他机构
院系归属:
医学院
第一中医临床学院
中西医结合学院
摘要:
Cerebral ischemia-reperfusion (CIR) is a serious complication often associated with cerebral ischemia. The pur-pose of this study was to explore the therapeutic effect of nourishing qi, activating blood circulation, and inducing resuscitation (Borneol with astragaloside IV and Panax notoginseng total saponins, BAP) on CIR. Neurological function score system was used to determine the neurological function. The survival of nerve cells was detected by Nissl staining. The levels of IL-1(3, IL-18, IL-4, and IL-10 were detected by ELISA. The expression of GSDMD, GSDMD-N, Nrf2, and HO-1 proteins in h...

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