MiR-99a inhibits keratinocyte proliferation by targeting Frizzled-5 (FZD5)/FZD8 through beta-catenin signaling in psoriasis

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成果类型：

期刊论文

作者：

Shen, Hui;Tian, Yi;Yao, Xiaolei;Liu, Wen;Zhang, Yujin;...

通讯作者：

Yang, Zhibo

作者机构：

[Zhang, Yujin; Shen, Hui; Yang, Zhibo; Liu, Wen; Tian, Yi] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Dermatol, Changsha, Hunan, Peoples R China.

[Shen, Hui] Guanxi Univ Chinese Med, Ruikang Hosp, Dept Dermatol, Nanning, Guangxi Provinc, Peoples R China.

[Yao, Xiaolei] Guanxi Univ Chinese Med, Ruikang Hosp, Dept Ophthalmol, Nanning, Guangxi Provinc, Peoples R China.

[Yang, Zhibo] 233 Caie North Rd, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Yang, Zhibo] 2

233 Caie North Rd, Changsha 410005, Hunan, Peoples R China.

语种：

英文

期刊：

Die Pharmazie

ISSN：

0031-7144

年：

2017

卷：

期：

页码：

461-467

DOI：

10.1691/ph.2017.7018

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573985]

机构署名：

本校为第一机构

院系归属：

第二中医临床医学院

摘要：

Psoriasis, a common chronic skin disorder, is characterized by hyperproliferation and aberrant differentiation of keratinocytes and infiltration of inflammatory cells into the dermis and epidermis. MicroRNAs (miRNAs) are a large family of highly conserved small non-coding RNA which regulates diverse biological process, including cell proliferation, by modulating gene expression at the posttranscriptional level. In the present study, we indicated that miR-99a was specifically downregulated in psoriatic dermatic lesions, and could inhibit HaCaT c...

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MiR-99a inhibits keratinocyte proliferation by targeting Frizzled-5 (FZD5)/FZD8 through beta-catenin signaling in psoriasis

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