Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion

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成果类型：

期刊论文

作者：

Chu, Shi-Feng;Zhang, Zhao;Zhang, Wei;Zhang, Mei-Jin;Gao, Yan;...

通讯作者：

Chen, NH

作者机构：

[Huang, Hui-Yong; Chen, Nai-Hong; Chen, NH; Chu, Shi-Feng] Hunan Univ Chinese Med, Collaborat Innovat Ctr Digital Tradit Chinese Med, Coll Pharm, Key Lab Diagnost Tradit Chinese Med, Changsha, Hunan, Peoples R China.

[Zhang, Mei-Jin; Zhang, Wei; Han, Ning; Gao, Yan; Chen, Nai-Hong; Zuo, Wei; Zhang, Zhao; Chen, NH; Chu, Shi-Feng] Chinese Acad Med Sci, Inst Mat Med, Ctr Neurosci, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China.

[Zhang, Mei-Jin; Zhang, Wei; Han, Ning; Gao, Yan; Chen, Nai-Hong; Zuo, Wei; Zhang, Zhao; Chen, NH; Chu, Shi-Feng] Peking Union Med Coll, Beijing, Peoples R China.

通讯机构：

[Chen, NH ] H

Hunan Univ Chinese Med, Collaborat Innovat Ctr Digital Tradit Chinese Med, Coll Pharm, Key Lab Diagnost Tradit Chinese Med, Changsha, Hunan, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Ctr Neurosci, State Key Lab Bioact Subst & Funct Nat Med, Beijing, Peoples R China.

Peking Union Med Coll, Beijing, Peoples R China.

语种：

英文

关键词：

binding protein;coumarin derivative;hepatitis B X interacting protein;imm h004;norphenazone;phosphatidylinositol 3 kinase;protein kinase B;survivin;transcription factor FKHR;unclassified drug;Birc5 protein, rat;coumarin derivative;HBXIP protein, human;IMM-H004;microtubule associated protein;neuroprotective agent;signal transducing adaptor protein;animal cell;animal experiment;animal model;animal tissue;apoptosis;Article;brain cortex;brain ischemia;complex formation;controlled study;drug dose comparison;hippocampal CA1 region;in vitro study;in vivo study;male;nerve cell necrosis;nonhuman;PC12 cell line;protein expression;protein phosphorylation;rat;animal;biosynthesis;drug effects;gene expression;genetics;metabolism;physiology;reperfusion injury;Sprague Dawley rat;transient ischemic attack;upregulation;Adaptor Proteins, Signal Transducing;Animals;Coumarins;Gene Expression;Ischemic Attack, Transient;Male;Microtubule-Associated Proteins;Neuroprotective Agents;Rats;Rats, Sprague-Dawley;Reperfusion Injury;Up-Regulation

期刊：

Molecular Neurobiology

ISSN：

0893-7648

年：

2017

卷：

期：

页码：

524-540

DOI：

10.1007/s12035-015-9673-5

基金类别：

This work was supported by the National Natural Science Foundation of China (No. 81274122, No. 81102831, No. 81173578), the National Key Sci-Tech Major Special Item (No. 2012ZX09301002-004, No. 2012ZX09103101-006), the National High-Tech R&D Program (863 Program) (No. 2012AA020303), the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT) (No. IRT1007), the Specialized Research Fund for the Doctoral Program of Higher Education of China (No. 20121106130001), the Beijing Natural Science Foundation (No. 7131013, No. 7142115), and the Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (No. BZ0150).

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

药学院

摘要：

IMM-H004, a 3-piperazinylcoumarin compound derived from coumarin, has been proved effective against CA1 cell loss and spatial learning impairments resulting from transient global ischemia/reperfusion (TGCI/R), while the mechanism is still largely unknown. Here, we confirmed that treatment of rats with IMM-H004 immediately after TGCI/R ameliorated delayed neuronal death (DND) in the CA1 of hippocampus and cortex. Further study suggested that IMM-H004 contributed to the expression of antiapoptotic protein survivin through the activation of PI3K-dependent protein kinase B (PKB/Akt), which led to ...

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Upregulating the Expression of Survivin-HBXIP Complex Contributes to the Protective Role of IMM-H004 in Transient Global Cerebral Ischemia/Reperfusion

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