期刊论文

Chen, Nai-Hong

英文

Molecular Neurobiology

0893-7648

2017

54

1

524-540

10.1007/s12035-015-9673-5

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81274122, 81102831, 81173578]; National Key Sci-Tech Major Special Item [2012ZX09301002-004, 2012ZX09103101-006]; National High-Tech R&D Program (863 Program)National High Technology Research and Development Program of China [2012AA020303]; Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT)Program for Changjiang Scholars & Innovative Research Team in University (PCSIRT) [IRT1007]; Specialized Research Fund for the Doctoral Program of Higher Education of ChinaSpecialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20121106130001]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7131013, 7142115]; Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study [BZ0150]

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IMM-H004, a 3-piperazinylcoumarin compound derived from coumarin, has been proved effective against CA1 cell loss and spatial learning impairments resulting from transient global ischemia/reperfusion (TGCI/R), while the mechanism is still largely unknown. Here, we confirmed that treatment of rats with IMM-H004 immediately after TGCI/R ameliorated delayed neuronal death (DND) in the CA1 of hippocampus and cortex. Further study suggested that IMM-H004 contributed to the expression of antiapoptotic protein survivin through the activation of PI3K-dependent protein kinase B (PKB/Akt), which led to ...