Renal interstitial fibrosis（RIF）is a pathological process characterized by a large accumulation of extracellular matrix replacing normal renal interstitium and renal tubular structure. Most of the chronic kidney diseases have a common pathological process when developing renal failure, and RIF is the end stage. It is regulated by various cytokines and multiple signaling pathways; the cross-talk between key signaling pathways and their joint action result in the final changes. Deeply understanding of the cross-talk between signaling pathways m...
