This research was funded by National Natural Science Foundation of China (grant number 81774208), the National Natural Science Foundation of Hunan (grant number 2019JJ50447, 2020JJ5408).
机构署名：
本校为第一机构
院系归属：
研究生院
摘要：
The potential role of the gut microbiome (GM) in heart failure (HF) had recently been revealed. However, the underlying mechanisms of the GM and fecal metabolome in HF have not been characterized. The Dahl salt-sensitive rat model of hypertensive heart failure (H-HF) was used to study the clinical symptoms and characteristics. To elucidate the pathogenesis of HF, we combined 16S rRNA gene sequencing and metabolomics to analyze gut microbial compositions and fecal metabolomic profiles of rats with H-HF. PCoA of beta diversity shown that the gut ...
