Anti-osteoporotic activity of the ethanol extracts of eucommia ulmoides in glucocorticoid-induced osteoporosis male rats through the activation of androgen receptor signaling

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成果类型：

期刊论文

作者：

Zhou, Chi;Zhang, Shuncong;Wang, Haibin;Dong, Lujue;Zhou, Guangquan;...

通讯作者：

Zhou, GQ

作者机构：

[Wang, Haibin; Zhou, Guangquan; Zhou, Chi; Zhang, Shuncong] Guangzhou Univ Tradit Chinese Med, Affiliated Hosp 1, 16 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

[Wang, Haibin; Feng, Pengbo; Dong, Lujue; Zhou, Chi; Zhang, Shuncong] Guangzhou Univ Tradit Chinese Med, Orthopaed Lab, Guangzhou 510405, Guangdong, Peoples R China.

[Song, Houpan] Hunan Univ Chinese Med, Hunan Prov Key Lab Diagnost Chinese Med, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Zhou, GQ ] G

Guangzhou Univ Tradit Chinese Med, Affiliated Hosp 1, 16 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.

语种：

英文

关键词：

androgen receptor;Eucommia ulmoides extract;glucocorticoid;testosterone;animal experiment;animal model;antiosteoporotic activity;Article;bone density;controlled study;corticosteroid induced osteoporosis;drug activity;gene expression;histopathology;male;nonhuman;protein expression;quantitative analysis;rat;reverse transcription polymerase chain reaction;sequence analysis;signal transduction;weight reduction;Western blotting

期刊：

International Journal of Clinical and Experimental Medicine

ISSN：

1940-5901

年：

2016

卷：

期：

页码：

2148-2156

基金类别：

This work was supported by National Natural Science Foundation of China (No. 81373665) and the Special Fund Project of Industrial Technology Research and Development in Guangdong Province (No. 2013B021800226). Province natural science fund of Guangdong (No. 2015A030310203); the Project of Youth Scientific Research Personnel Training in Guangdong Province (No. 2015QN01).

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本校为其他机构

院系归属：

中医学院

摘要：

Objective: The present study systematically investigated the in vivo effect of ethanol extracts of eucommia ulmoides (EE-EU) on bone deteriorations in GIOP rat, which was a secondary osteoporosis experimental animal model. This animal model has typical pathologic manifestation and good replication, and could be used to study the effect of drugs. Methods: Forth 6-week-old male Sprague-Dawley rats were randomly divided into vehicle-operated group, prednisone acetate (PA) group, PA with EE-EU of graded doses (100 mg/kg/day or 500 mg/kg/day). The biomarkers in serum and urine were measured, tibias...

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Anti-osteoporotic activity of the ethanol extracts of eucommia ulmoides in glucocorticoid-induced osteoporosis male rats through the activation of androgen receptor signaling

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