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The Antitumor and Immunomodulatory Effect of Yanghe Decoction in Breast Cancer Is Related to the Modulation of the JAK/STAT Signaling Pathway

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成果类型:
期刊论文
作者:
Mao, Dan;Feng, Lei*;Gong, Hui
通讯作者:
Feng, Lei
作者机构:
[Mao, Dan] Cent South Univ, Xiangya Hosp 2, Dept Integrated Tradit Chinese & Western Med, Changsha 410000, Hunan, Peoples R China.
[Feng, Lei] Liuyang Hosp Tradit Chinese Med, Dept Oncol, Liuyang 410300, Hunan, Peoples R China.
[Gong, Hui] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Oncol, Changsha 410006, Hunan, Peoples R China.
通讯机构:
[Feng, Lei] L
Liuyang Hosp Tradit Chinese Med, Dept Oncol, Liuyang 410300, Hunan, Peoples R China.
语种:
英文
期刊:
Evidence-Based Complementary and Alternative Medicine
ISSN:
1741-427X
年:
2018
卷:
2018
页码:
8460526
基金类别:
Research Project of Hunan Provincial Department of Education [17C1205]
机构署名:
本校为其他机构
摘要:
Background: Yanghe decoction (YHD) has been used in the treatment of breast cancer for hundreds of years in Asia. However, the underlying mechanisms are currently unknown. The present study aims to evaluate the efficacy of YHD on antitumor and immune system enhancement in a 4T1 mouse breast cancer model and to clarify the antitumor mechanisms of YHD in breast cancer. Materials and Methods: The YHD was orally administrated for 2 weeks after inoculation. Tumor tissues were then removed, weighed, and homogenized. Flow cytometry was used to detect the number of Myeloid-Derived Suppressor Cells (MD...

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