Objective To analyze the therapeutic effect and Security of affective on mania in cure of stereotaetic surgery. Methods 40 patients who suffered affective on Recurrent Mania were treated by stereotactic technique combined with bilateral amygdaloid nuclei, callosal gyrus, nucleus accumbens septi lesion by radio-frequency thermocoagulation. The therapeutic effects were estimated with CGI, BRMS, PANSS,BPRS, ADL, SDSS at the second week, sixth month and the first year after surgery. Results The score of the CGI,BRMS,PANSS,BPRS,ADL and SDSS before s...