Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice

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成果类型：

期刊论文

作者：

Gong, Jun;Fang, Chun;Zhang, Peng;Wang, Pi-Xiao;Qiu, Yixing;...

通讯作者：

Zhang, XD;She, ZG;Wang, AB

作者机构：

[Gong, Jun; Zhang, Xiao-Dong; Zhang, XD; Huang, Zan] Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, 16 Luo Jia Shan Rd, Wuhan 430072, Hubei, Peoples R China.

[She, Zhi-Gang; Zhang, Peng; Tian, Song; Zhu, Xue-Yong; Zhang, Li; Li, Feng; Wang, Zhihua; Huang, Zan; Shen, Li-Jun; Wang, Pi-Xiao; Fang, Chun] Wuhan Univ, Sch Basic Med, Wuhan, Hubei, Peoples R China.

[She, Zhi-Gang; Zhang, Peng; Tian, Song; Zhu, Xue-Yong; Zhang, Li; Li, Feng; Wang, Zhihua; Shen, Li-Jun; Wang, Pi-Xiao; Fang, Chun] Wuhan Univ, Inst Model Anim, Wuhan, Hubei, Peoples R China.

[She, Zhi-Gang; Zhang, Peng; Tian, Song; Zhu, Xue-Yong; Zhang, Li; Wang, Zhihua; Shen, Li-Jun; Wang, Pi-Xiao; Fang, Chun] Wuhan Univ, Sch Med, Med Res Inst, Wuhan, Hubei, Peoples R China.

[She, Zhi-Gang; Wang, Zhihua; She, ZG] Wuhan Univ, Renmin Hosp, Dept Cardiol, Jie Fang Lu 238, Wuhan 430060, Hubei, Peoples R China.

通讯机构：

[She, ZG ; Zhang, XD ] W

[Wang, AB ] H

Wuhan Univ, Coll Life Sci, Hubei Key Lab Cell Homeostasis, 16 Luo Jia Shan Rd, Wuhan 430072, Hubei, Peoples R China.

Wuhan Univ, Renmin Hosp, Dept Cardiol, Jie Fang Lu 238, Wuhan 430060, Hubei, Peoples R China.

Hunan Agr Univ, Coll Vet Med, Nongda Rd,Vet Med Bldg, Changsha 410128, Hunan, Peoples R China.

语种：

英文

期刊：

Hepatology

ISSN：

0270-9139

年：

2019

卷：

期：

页码：

524-544

DOI：

10.1002/hep.29820

基金类别：

Potential conflict of interest: Nothing to report. Supported by grants from the National Natural Science Foundation of China (No. 81770053, 81470375, and 91729303), the National Science and Technology Support Project (2016YFF0101500), the Key Collaborative Project of the National Natural Science Foundation (91639304), and Shennong Scholar funding of Hunan Agricultural University (to A.-B.W.).

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Tumor progression locus 2 (TPL2), a serine/threonine kinase, has been regarded as a potentially interesting target for the treatment of various diseases with an inflammatory component. However, the function of TPL2 in regulating hepatocyte metabolism and liver inflammation during the progression of nonalcoholic fatty liver disease (NAFLD) is poorly understood. Here, we report that TPL2 protein expression was significantly increased in fatty liver from diverse species, including humans, monkeys, and mice. Further investigations revealed that compared to wild-type (WT) littermates, hepatocyte-sp...

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Tumor Progression Locus 2 in Hepatocytes Potentiates Both Liver and Systemic Metabolic Disorders in Mice

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