Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression

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成果类型：

期刊论文

作者：

Sun, Si-yu;Cao, Yu-mei;Huo, Yan-jie;Qiu, Fei;Quan, Wen-juan;...

通讯作者：

Qin-hui Tuo

作者机构：

[Liao, Duan-fang; Sun, Si-yu; Quan, Wen-juan; Huo, Yan-jie; Cao, Yu-mei; Qiu, Fei; Tuo, Qin-hui; Chen, Yu; He, Chao-ping] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

[Sun, Si-yu] Xinxiang Med Univ, Cardiovasc Res Ctr, Affiliated Hosp 1, Xinxiang, Henan, Peoples R China.

[Qiu, Fei] Hunan Univ Med, Dept Pharm, Affiliated Hosp 1, Huaihua, Hunan, Peoples R China.

[Tuo, Qin-hui] Hunan Univ Chinese Med, Sch Med, Changsha, Peoples R China.

通讯机构：

[Qin-hui Tuo] S

School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>School of Medicine, Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Nicotinate-curcumin;vascular smooth muscle cells;phenotype switching;Daxx

期刊：

Cell Adhesion & Migration

ISSN：

1933-6918

年：

2021

卷：

期：

页码：

116-125

DOI：

10.1080/19336918.2021.1909899

基金类别：

The work was supported by National Natural Science Foundation of China [81673722, 81600291, 81670268], The National Natural Science Foundation of Hunan [2019JJ50426] The Education Department of Hunan Province [20A379, 19B401].

机构署名：

本校为第一机构

院系归属：

医学院

药学院

摘要：

Phenotypic switching is the main cause of the abnormal proliferation and migration of vascular smooth muscle cells (VSMCs). We previously showed that Daxx exerted negative regulatory effect on AngII-induced VSMC proliferation and migration. However, the function of Daxx in VSMC phenotype switching remained unknown. Nicotinate-curcumin (NC) is an esterification derivative of niacin and curcumin that can prevent the formation of atherosclerosis. We found that NC significantly decreased AngII-induced VSMC phenotype switching. Furthermore, NC significantly inhibited AngII-induced cell proliferatio...

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Nicotinate-curcumin inhibits AngII-induced vascular smooth muscle cell phenotype switching by upregulating Daxx expression

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