期刊论文

中文

胃肠病学和肝病学杂志

1006-5709

2013

22

5

431-433

10.3969/j.issn.1006-5709.2013.05.012

基金项目：国家自然科学基金资助项目（81072867）

本校为第一机构

目的 尝试在SPF级SD大鼠胃内定植H.pylori,以建立大鼠H.pylori感染胃炎模型.方法 选用SD大鼠30只,随机分为5组,即对照组及4个模型组,模型组分别予NaHCO3溶液、56％酒精、消炎痛溶液、NaHCO3+消炎痛溶液联合H.pylori菌液灌胃造模,灌胃隔天1次,连续5次,并于最后一次灌胃结束后第2、4、6周处死大鼠,取胃黏膜组织分别记录损伤指数、进行快速尿素酶试验、胃黏膜涂片及病理切片.结果每组大鼠数、快速尿素酶试验及革兰染色阳性数:NaHCO3溶液+H.pylori组分别为6、4、4,56％酒精+H.pylori组分别为6、6、1,消炎痛溶液+H.pylori组分别为5、4、4,NaHC03+消炎痛溶液+H.pylori组分别为4、4、4.损伤指数及病理切...

Objective To establish the rat model of gastritis with H. pylori infection. Methods 30 SD rats were randomly divided into 5 groups, including control group and four model groups, model groups were given NaHCO3 solu- tion, 56% alcohol solution, indomethacin, NaHCOf indomethaein solution combined with H. pylori bacteria liquid in each group once every other day, 5 times in a row, rats were sacrificed after 2, 4, 6 weeks, and gastric mucosa damage index, rapid urease test, gastric mueosal smears and histologic sections were recorded. Results The r...