期刊论文

中文

现代中西医结合杂志

1008-8849

2019

28

28

3091-3095+3118

10.3969/j.issn.1008-8849.2019.28.004

湖南省中医药科研计划重点项目(201753) 国家自然科学基金面上项目(81473616) 国家科学基金青年基金项目(81804077) 湖南省自然科学基金(青年基金)(2019JJ50468)。

本校为第一机构

目的 观察养阴柔肝、化瘀息风法对自发性高血压大鼠(SHR)血压及炎症因子的影响.方法 将144只8周龄SPF级雄性SHR大鼠随机分为模型组、MRS2578组、复方七芍降压片组、厄贝沙坦组、MRS2578+复方七芍降压片组、MRS2578+厄贝沙坦组,每组24只;另选择24只健康、SPF级雄性WKY大鼠作为对照组.模型组和对照组大鼠给予蒸馏水灌胃,其他各组大鼠给予相应药物干预,其中复方七芍降压片流浸膏剂量为0.65 mL,厄贝沙坦剂量为3.63 mg,MRS2578按3 mg/kg腹腔注射(隔日1次).各组灌胃均1次/d,连续8周.记录各组实验前及实验开始后每周最后一天14:00—17:00每只大鼠的尾动脉血压,采用ELISA法检测各组大鼠实验第1,4,8周最后...

Objective It is to observe the effects of Yangyin Rougan and Huayu Xifeng on blood pressure and inflammatory factors in the rats with spontaneously hypertension(SH).Methods A total of 144 8-week-old SPF male SH rats were randomly divided into model group,MRS2578 group,compound Qishao Jian gya tablet group,irbesartan group,MRS2578+compound Qishao Jiangya tablet group,MRS2578+irbesartan groups,24 rats in each group.Another 24 healthy SPF male WKY rats were selected as the control group.The rats in the model group and the control group were given ...