期刊论文

中文

现代中西医结合杂志

1008-8849

2020

29

17

1834-1838

10.3969/j.issn.1008-8849.2020.17.003

湖南省自然科学基金资助项目(2018JJ6038) 湖南省中医药科研计划项目(201703) 湖南省学位与研究生教育改革研究项目(2019JGYB163)。

本校为第一机构

目的 探讨柴胡三参胶囊抗缺血性心律失常的作用及分子学作用机制.方法 将60只SPF级雄性Wistar大鼠随机分为柴胡三参胶囊组、参松养心胶囊组、维拉帕米组、假手术组、模型组和空白组,每组10只.柴胡三参胶囊组、参松养心胶囊组、维拉帕米组预防性给予相应药物灌胃,假手术组、模型组和空白组灌胃等量的生理盐水,连续灌胃2周后,柴胡三参胶囊组、参松养心胶囊组、维拉帕米组大鼠均复制缺血性心律失常模型,假手术组大鼠只穿线不结扎,观察各组大鼠ECG变化,Western blot法检测心肌组织中CaMKⅡ蛋白表达水平,定量PCR法检测心肌组织中CaMKⅡmRNA表达水平.结果 模型组大鼠房性早搏、室早、室速、室颤发生率...

Objective It is to explore the effect and molecular mechanism of Chaihu Sanshen capsules against ischemic arrhythmia.Methods Sixty SPF male Wistar rats were randomly divided into Chaihu Sanshen capsule group,Shensong Yangxin capsule group,verapamil group,sham operation group,model group and blank group,10 rats in each group.Chaihu Sanshen capsule hroup,Shensong Yangxin capsule group and verapamil group were given the preventive corresponding medicine by gavage,and sham operation group,model group and blank group were given the same amount of no...