期刊论文

中文

中国比较医学杂志

1671-7856

2014

10

48-53+66

10.3969/j.issn.1671.7856.2014.010.009

国际科技合作专项一人参益智药效与基因/蛋白表达谱关联规律合作研究（编号：2011DFA32730） 全军医学科技“十二五”科研项目（编号：BWS11J052） 极限环境认知损伤保护药临床前药效评价技术体系.国家科技重大专项课题（编号：2012ZX09J12201） 湖南中医药大学病理学与病理生理学重点学科（2012）.

本校为第一机构

目的：研究达玛烷苷元（ dammarane sapogenins，DS-1226）对睡眠干扰（ sleep interruption， SI）致认知障碍小鼠学习记忆能力的影响。方法将ICR小鼠随机分为对照组，模型组，DS-1226低、中、高三个剂量组。用改良滚筒法对小鼠进行睡眠干扰，同时灌胃给药15 d后，用自主活动仪检测自主活动，水迷宫、避暗实验检测学习记忆能力。结果与模型组比较，DS-1226各给药组总路程、平均速度、运动总时间均增加。模型组水迷宫定位航行D5、D6潜伏期增加；与模型组和低剂量组比较，DS-1226中剂量组D6潜伏期降低，高剂量组D1-D6潜伏期降低；与中剂量组比较，DS-1226高剂量组D1-D5潜伏期降低。模型组水迷宫空...

Objective To study the effects of dammarane sapogenins ( DS-1226 ) on sleep interruption-induced learning and memory impairment in mice.Methods 130 SPF healthy 5 -6-week old male ICR mice were randomly divided into control, model, DS-1226 low dose, DS-1226 medium dose and DS-1226 high dose groups.The behavioral alterations in open field (OF), Morris water maze (MWM) and step-through (ST) tests were detected at 15 days after rotating drum-induced sleep interruption ( SI) .Results The total distance, movement speed, total duration of movement were increased in OF test ( P