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ATP-Binding Membrane Cassette Transporter A1 (ABCA1): A Possible Link between Inflammation and Reverse Cholesterol Transport

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成果类型:
期刊论文
作者:
Yin, Kai;Liao, Duan-fang;Tang, Chao-ke*
通讯作者:
Tang, Chao-ke
作者机构:
[Tang, Chao-ke; Yin, Kai] Univ S China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
[Liao, Duan-fang] Hunan Univ Chinese Med, Sch Pharm, Dept Tradit Chinese Diagnost, Changsha, Hunan, Peoples R China.
通讯机构:
[Tang, Chao-ke] U
Univ S China, Inst Cardiovasc Res, Life Sci Res Ctr, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
ABCA1-mediated Cholesterol Efflux;ABCA1-deficient Mice;C/EBP Homologous Protein;Cholesterol Export;Familial Hypoalphalipoproteinemia
期刊:
Molecular Medicine
ISSN:
1076-1551
年:
2010
卷:
16
期:
9-10
页码:
438-449
基金类别:
National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30470720]; Post-doctor Sciences Foundation of ChinaChina Postdoctoral Science Foundation [2005037157]; Hunan Provincial Natural Sciences Foundation of China [10JJ9019]
机构署名:
本校为其他机构
院系归属:
中医学院
药学院
摘要:
Atherosclerosis is characterized by a chronic inflammatory condition that involves numerous cellular and molecular inflammatory components. A wide array of inflammatory mediators, such as cytokines and proteins produced by macrophages and other cells, play a critical role in the development and progression of the disease. ATP-binding membrane cassette transporter A1 (ABCA1) is crucial for cellular cholesterol efflux and reverse cholesterol transport (RCT) and is also identified as an important target in antiatherosclerosis treatment. Evidence f...

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