期刊论文

中文

中国临床药理学与治疗学

1009-2501

2009

14

10

1133-1136

本校为第一机构

目的:探讨多西环素对内毒素性急性肺损伤的影响及机制.方法:将昆明小鼠随机分为:生理盐水对照组、多西环素组、内毒素脂多糖(LPS)急性肺损伤模型组及多西环素干预组.注射LPS24 h后处死动物,行支气管肺泡灌洗(BALF),计数灌洗液中白细胞数量及测定总蛋白含量.用ELISA分别测定肺组织匀浆上清液中TNF-a、基质金属蛋白酶-9(MMP-9)和金属蛋白酶组织抑制剂-1(TIMP-1)的含量.同时取肺组织进行病理学观察,测定肺组织湿/干重比值.结果:多西环素显著减少LPS所致BALF中白细胞数量、总蛋白浓度和肺组织湿/干重比值(P＜0.01).多西环素能降低肺组织匀浆上清液中TNF-a和MMP-9含量(P＜0.01),轻度上调TIMP-1的含量...

AIM：To investigate the potential role and of Doxycycline in lipopolysaccharide-induced acute lung injury in mice and its possible mechanism.METHODS：Kunming mice were treated with Doxycycline （20 mg/kg） or saline an hour before LPS administration （10 mg/kg） by intraperitoneal injection and were decapitated 24 h after LPS challenge.The bronchoalveolar lavage fluid （BALF） samples were analyzed for total protein concentrateion and white blood cell （WBC） count.The lung samples were taken for histopathological evaluation and for determinati...