期刊论文

Effect of Qingre Jiedu Huazhuo Tablets on IL-8 and IL-10 in Rat Model of Liver and Lung Injuries Induced by Intestinal Endotoxemia

中文

云南中医学院学报

1000-2723

2015

38

6

17-20,24

10.19288/j.cnki.issn.1000-2723.2015.06.005

12A101:湖南省教育厅重点项目 CX2015B322:湖南省教育厅研究生创新性项目 :湖南中医药大学中医临床基础重点学科建设项目 :湖南省方剂学重点学科建设项目

本校为第一机构

目的 探讨清热解毒化浊片对肠源性内毒素血症(IETM)大鼠肝肺促炎因子IL-8及抗炎因子IL-10的影响.方法 采用高脂、糖、酒精复合因素干预12周建立IETM肝肺损伤大鼠模型.造模成功后,随机分为清热解毒化浊片组、模型组和正常组3组.经治疗4周后观察肝、肺组织病理学改变,采用全自动生化仪检测血清谷氨酰氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰氨基转移酶(GGT)、碱性磷酸酶(ALP)活性,动态浊度法检测血浆内毒素(LPS),免疫组化二步法测定IL-8、IL-10在肝肺组织中的表达.结果 光镜下观察,清热解毒化浊片组大鼠肝、肺组织炎性浸润情况明显改善.与正常组比较,模型组血清ALT、AST、GGT、ALP明显...

Objective To study effect of Qingre Jiedu Huazhuo tablets on IL-8 and IL-10 in rat model of liver and lung injuries induced by intestinal endotoxemia（IETM）. Methods The rat liver model was established by feeding them high sugar, fat and liquor. The rats were randomly divided into 3 groups. Qingre Jiedu Huazbuo tablets were used to treat liver inflammatory model rat for 4 weeks. The content of blood serum alanine transaminase（ALT）, aspartate transaminase（AST）, gamma glutamyltransferase （GGT）, alkaline phosphatase（ALP） were measured by ...