Guhan Yangsheng Jing mitigates hippocampal neuronal pyroptotic injury and manifies learning and memory capabilities in sleep deprived mice via the NLRP3/Caspase1/GSDMD signaling pathway.

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成果类型：

期刊论文

作者：

Fu, Xinying;Yan, Siyang;Hu, Zongren;Sheng, Wen;Li, Wanyu;...

通讯作者：

Liu, Lumei;Zhang, Wei;He, Qinghu

作者机构：

[Fu, Xinying; He, Qinghu; Li, Wanyu] College of Integrated Chinese and Western Medicine, Hunan Provincial Key Laboratory for Prevention and Treatment of Heart and Brain Diseases with Integrated Traditional Chinese and Western Medicine, Hunan University of Traditional Chinese Medicine, Hunan, 410208, China

[Fu, Xinying; He, Qinghu] College of Integrated Chinese Medicine, Hunan University of Traditional Chinese Medicine, Hunan, 410208, China

[Fu, Xinying] Hunan University of Medicine, Huaihua, Hunan, 418000, China

[Yan, Siyang] The First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha, Hunan, 410007, China

[Sheng, Wen; Kuang, Shida; Hu, Zongren] College of Integrated Chinese Medicine, Hunan University of Traditional Chinese Medicine, Hunan, 410208, China

通讯机构：

[He, Qinghu] H

[Zhang, Wei; Liu, Lumei] C

College of Integrated Chinese and Western Medicine, Hunan Provincial Key Laboratory for Prevention and Treatment of Heart and Brain Diseases with Integrated Traditional Chinese and Western Medicine, Hunan University of Traditional Chinese Medicine, Hunan, 410208, China. Electronic address:

Hunan University of Medicine, Huaihua, Hunan, 418000, China. Electronic address:

语种：

英文

关键词：

GuHan YangSheng jing;Hippocampal neuronal detriment;Learning and memory capabilities;NLRP3/Caspase1/GSDMD signaling pathway;Sleep deprivation

期刊：

Journal of Ethnopharmacology

ISSN：

0378-8741

年：

2024

卷：

326

页码：

117972

DOI：

10.1016/j.jep.2024.117972

机构署名：

本校为第一且通讯机构

摘要：

ETHNOPHARMACOLOGICAL RELEVANCE: Guhan Yangsheng Jing (GHYSJ) is a traditional Chinese patent medicine, that has the function of nourishing the kidney and replenishing the essence, invigorating the brain and calming the mind. It is often used to treat dizziness, memory loss, sleep disorders, fatigue, and weakness, etc. However, its mechanism for improving sleep has not yet been determined. AIM OF THE STUDY: This study aims to explore the effects of GHYSJ on Sleep Deprivation (SD)-induced hippocampal neuronal pyroptotic injury, learning and cogni...

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Guhan Yangsheng Jing mitigates hippocampal neuronal pyroptotic injury and manifies learning and memory capabilities in sleep deprived mice via the NLRP3/Caspase1/GSDMD signaling pathway.

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