TP53/miR-129/MDM2/4/TP53 feedback loop modulates cell proliferation and apoptosis in retinoblastoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Yao, Xiaolei;Shen, Hui;Peng, Qinghua;Yu, Jingsheng

通讯作者：

Xiaolei Yao<&wdkj&>Hui Shen

作者机构：

[Yao, Xiaolei; Yu, Jingsheng; Shen, Hui] Hunan Univ Chinese Med, Hosp 1, Dept Ophthalmol, Changsha, Peoples R China.

[Yao, Xiaolei; Peng, Qinghua] Hunan Univ Chinese Med, Hunan Prov Key Lab Prevent & Treatment Ophthalmol, Changsha, Peoples R China.

[Yao, Xiaolei; Peng, Qinghua] Hunan Univ Chinese Med, Otolaryngol Dis Tradit Chinese Med, Changsha, Peoples R China.

[Yao, Xiaolei; Peng, Qinghua] Ear Nose & Throat Dis Hunan Prov, Key Lab Tradit Chinese Med Prevent & Treatment Ey, Changsha, Peoples R China.

[Peng, Qinghua] Hunan Univ Chinese Med, Clin Coll 1, Changsha, Peoples R China.

通讯机构：

[Xiaolei Yao; Hui Shen] D

Department of Ophthalmology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Hunan Provincial Key Laboratory for the Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, China<&wdkj&>Key Laboratory of Traditional Chinese Medicine for Prevention and Treatment of Eye, Ear, Nose and Throat Diseases in Hunan Province, Changsha, China<&wdkj&>Department of Ophthalmology, The First Hospital of Hunan University of Chinese Medicine, Changsha, China

语种：

英文

关键词：

Retinoblastoma (RB);p53;miR-129;MDM2;feedback loop

期刊：

Cell Cycle

ISSN：

1538-4101

年：

2021

卷：

期：

5-6

页码：

603-615

DOI：

10.1080/15384101.2021.1892321

基金类别：

Hunan Provincial Key Laboratory Construction Project for Prevention and Treatment of Ophthalmology and Otolaryngology Diseases with Chinese Medicine (2017TP1018) and National Administration of Traditional Chinese Medicine Key Discipline Construction Project of Ophthalmology of Traditional Chinese Medicine (ZK1801YK015). This study was supported by Key Laboratory of Hunan Provincial Key Laboratory for Preventing and Treating Five Diseases of Obstetrics and Gynecology (2017TP1018); Key Subject Construction Project of Traditional Chinese Medicine Ophthalmology of the State Administration of Traditional Chinese Medicine (ZK1801YK015) and Science and Technology Plan of Changsha City (K1501014-31, kc1704005).

机构署名：

本校为第一机构

院系归属：

第一中医临床学院

摘要：

Retinoblastoma (RB) is commonly-seen cancer in children. The p53 pathway dysfunction, which can lead to elevated MDM2 or MDM4 (p53 antagonists) protein expression, is frequently observed in almost all human cancers, including RB. The present study attempted to investigate the underlying mechanism from the perspective of non-coding RNA regulation. Here, we demonstrated that p53 and miR-129 were positively correlated with each other in RB. miR-129 directly targeted MDM2/4 to inhibit expression, therefore counteracting MDM2/4-mediated p53 signaling suppression and modulating RB cell proliferation...

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TP53/miR-129/MDM2/4/TP53 feedback loop modulates cell proliferation and apoptosis in retinoblastoma

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