期刊论文

中文

中国医学创新

1674-4985

2015

31

10-13

10.3969/j.issn.1674-4985.2015.31.004

81473616:国家自然科学基金 2013SK2025:湖南省科技计划 201403:湖南省中医药科研项目 ZYFT201407:湖南省中药粉体与创新药物研究省部共建国家重点实验室培育基地开放基金

本校为第一机构

目的:观察复方七芍降压片对自发性高血压大鼠（SHR）的降压作用及其对血清IL-6、IL-8和TNF-α的影响。方法:以12只8周龄Wistar—kyoto（WKY）大鼠为正常组（WKY组）,48只8周龄SHR随机分为4组,即模型组（SHR-M组）、卡托普利组（SHR-K组）、复方七芍降压片低剂量治疗组（SHR-D组）、复方七芍降压片高剂量治疗组（SHR-G组）。连续灌胃4周,观察比较各组血压及血清中IL-6、IL-8和TNF-α变化。结果:SHR-K组血压从第1周开始,SHR-D组血压从第3周开始,SHR-G组血压从第2周开始均低于治疗前及SHR-M组,比较差异均有统计学意义（P

Objective：To explore the effect of Compound Qishaojiangya tablet on blood pressure and IL-6, IL-8,TNF-α in rats with spontaneously hypertension.Method：Twelve 8-week-old Wistar-kyoto（WKY） rats were selected as the normal group,forty-eight 8-week-old spontaneously hypertension rats （SHR） were selected and divided into 4 groups randomly,with each group 12 rates.The 4 groups were the model group（group SHR-M）,the Captopril group（group SHR-K）,the Compound Qishaojiangya tablet low-dose group（group SHR-D） and the Compound Qishaojiangya tab...