Circular RNA PVT1 enhances cell proliferation but inhibits apoptosis through sponging microRNA-149 in epithelial ovarian cancer

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成果类型：

期刊论文

作者：

Sun, Xiaofeng;Luo, Ling;Gao, Yuqiang

通讯作者：

Gao, YQ

作者机构：

[Sun, Xiaofeng] Hunan Univ Chinese Med, Sch Med, Dept Histol & Embryol, Changsha, Peoples R China.

[Luo, Ling] Cent South Univ, Dept Orthoped, Xiangya Hosp 3, Changsha, Peoples R China.

[Gao, Yuqiang] Zaozhuang Municipal Hosp, Dept Clin Lab, 41 Longtou Zhong Rd, Zaozhuang 277102, Shangdong, Peoples R China.

通讯机构：

[Gao, YQ ] Z

Zaozhuang Municipal Hosp, Dept Clin Lab, 41 Longtou Zhong Rd, Zaozhuang 277102, Shangdong, Peoples R China.

语种：

英文

关键词：

circular ribonucleic acid;circular RNA PVT1;microRNA;microRNA 149;microRNA 183;microRNA 194;unclassified drug;long untranslated RNA;microRNA;MIRN149 microRNA, human;PVT1 long-non-coding RNA, human;apoptosis;Article;Caov-3 cell line;carcinogenesis;cell proliferation;controlled study;female;gene expression regulation;gene identification;gene knockdown;gene overexpression;gene targeting;human;human cell;ovarian carcinoma cell line;ovary carcinoma;OVCAR-3 cell line;quantitative analysis;real time polymerase chain reaction;RNA binding;RNA processing;RNA sponging;SK-OV-3 cell line;SNU119 cell;apoptosis;cell proliferation;genetics;ovary tumor;tumor cell line;Apoptosis;Carcinoma, Ovarian Epithelial;Cell Line, Tumor;Cell Proliferation;Female;Humans;MicroRNAs;Ovarian Neoplasms;RNA, Circular;RNA, Long Noncoding

期刊：

JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH

ISSN：

1341-8076

年：

2020

卷：

期：

页码：

625-635

DOI：

10.1111/jog.14190

基金类别：

This study was supported by National Natural Science Foundation of China (Nos. 81774362; 81303004) and National Natural Science Foundation of Hunan (No. 2018JJ2290).

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

Aim: This study aimed to investigate the influence of circular RNA PVT1 (circ-PVT1) on epithelial ovarian cancer (EOC) cell proliferation and apoptosis, more importantly, to identify the target microRNAs (miRNA) of circ-PVT1 in EOC. Methods: Circ-PVT1 expression in EOC cell lines and nonmalignant control cells was detected. Cell proliferation, apoptosis and candidate target miRNA (miR-149, miR-183 and miR-194) expressions were detected in circ-PVT1 overexpression treated CAOV3 cells and circ-PVT1 knock-down treated SKOV3 cells. Furthermore, miR...

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Circular RNA PVT1 enhances cell proliferation but inhibits apoptosis through sponging microRNA-149 in epithelial ovarian cancer

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