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Antiviral signaling of a type III CRISPR-associated deaminase

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成果类型:
期刊论文
作者:
Yutao Li;Zhaoxing Li;Purui Yan;Chenyang Hua;Jianping Kong;...
通讯作者:
Meiling Lu<&wdkj&>Meirong Chen<&wdkj&>Yibei Xiao
作者机构:
[Shunli Ji] Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China.
[Yan Duan; Shunxiang Li] School of Pharmacy, Hunan University of Chinese Medicine, Changsha, China.
[Guanglei Li] College of Food Science and Engineering, Nanjing University of Finance and Economics, Nanjing, China.
通讯机构:
[Meiling Lu] S
[Meirong Chen; Yibei Xiao] D
Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing, China.<&wdkj&>State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.<&wdkj&>Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China.<&wdkj&>State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.<&wdkj&>Chongqing Innovation Institute of China Pharmaceutical University, Chongqing, China.<&wdkj&>Department of Biochemistry, School of Life Science and Technology, China Pharmaceutical University, Nanjing, China.
语种:
英文
期刊:
Science
ISSN:
0036-8075
年:
2025
卷:
387
期:
6736
页码:
eadr0393
基金类别:
National Natural Science Foundation of China : 32271330 National Natural Science Foundation of China : 82304614 National Natural Science Foundation of China : 82473977 National Natural Science Foundation of China : 82321005 National Natural Science Foundation of China : 32471316 Ministry of Science and Technology of the People´s Republic of China: 2023YFC3402300 Ministry of Science and Technology of the People´s Republic of China: 2021ZD0203400 Fundamental Research Funds for the Central Universities : 2632023GR17
机构署名:
本校为其他机构
院系归属:
药学院
摘要:
Prokaryotes have evolved diverse defense strategies against viral infection, including foreign nucleic acid degradation by CRISPR-Cas systems and DNA and RNA synthesis inhibition through nucleotide pool depletion. Here, we report an antiviral mechanism of type III CRISPR-Cas–regulated adenosine triphosphate (ATP) depletion in which ATP is converted into inosine triphosphate (ITP) by CRISPR-Cas–associated adenosine deaminase (CAAD) upon activation by either cA 4 or cA 6 , followed by hydrolysis into inosine monophosphate (IMP) by Nudix hydrola...

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