期刊论文

英文

International Immunopharmacology

1567-5769

2022

113

Pt A

109349

10.1016/j.intimp.2022.109349

National Natural Science Foundation of China [81874476]; project of the National Famous and Old Chinese Medicine Experts Inheritance Studio of the National Administration of Traditional Chinese Medicine [75]; Hunan Provincial Administration of Traditional Chinese Medicine's "14th Five-Year Plan" first batch of TCM leading talent training projects; Health Commission of Hunan Province [202104070364, 20200442, 20200440]; Hunan Administration of Traditional Chinese Medicine [D2022067, 2021236]; First-class Discipline Construction Project of Hunan University of Chinese Medicine [2021ZYX32, 2021ZYX16, 2021ZYX08]; Postgraduate Innovation Project of Hunan University of Chinese Medicine [2021CX25, 2021CX71]

本校为第一机构

Osteoarthritis (OA) is a common degenerative disease with few treatments. In traditional Chinese medicine (TCM), Radix Angelicae biseratae (RAB) is commonly used to treat OA. Nodakenin (Nod) is one main coumarin active component in RAB and exhibits anti-inflammatory, anti-oxidative, and anti-apoptotic effects. Reactive oxygen species (ROS) produced by mitochondria play a vital role in the pathogenesis of OA. We hypothesized that Nod might ameliorate cartilage degradation and inflammatory responses by regulating the mitochondrial Drp1/ROS/NLRP3 ...