期刊论文

Intervening Effects of Taohongsiwu Decoction on Callus Micrangium Regeneration and Expression of VEGF

中文

中国医师杂志

1008-1372

2004

6

2

195-197

10.3760/cma.j.issn.1008-1372.2004.02.021

湖南省自然科学基金

本校为第一机构

目的研究桃红四物汤对骨折断端骨痂组织内微血管新生重建及VEGF表达的影响.方法利用日本大耳白兔65只随机分成四组:三组作右前肢桡骨中段手术骨折造模并分别给予桃红四物汤、炎迪宁片、蒸馏水灌胃,另一组为正常对照组,在骨折后7、15、21、35d,采用免疫组化方法检测骨痂组织中VEGF表达,组织学染色检测骨痂组织内微血管变化,并作计数对比分析.结果桃红四物汤干预组VEGF表达量高于其它各组,并在第15d表达峰值后下降不显著,同时,各时相点骨痂微血管增殖和塑形优于其他各组.结论桃红四物汤通过提高骨折后骨痂内VEGF的表达,加速断端微血管新生重建,促进骨折愈合.

Objective To study the effect of Taohongsiwu decoction(THSWD) on the VEGF expression and the micrangium regeneration of callus tissue in bone stump. Methods 65 Japanese rabbits were divided into four groups randomly, three groups were given orally with THSWD, Yandining tablet, distilled water respectively after the right radial bone fracture model was established by operation, and the other group served as control. At the 7th,15th,21th and 35th day after fracture, immunohistochemical method was used to detect the expression of VEGF, and the histochemical staining was used to detect the micrang...