Oxidized low-density lipoprotein induced mouse hippocampal HT-22 cell damage via promoting the shift from autophagy to apoptosis

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成果类型：

期刊论文

作者：

Gu, Hong-Feng;Li, Hai-Zhe;Xie, Xue-Jiao;Tang, Ya-Ling;Tang, Xiao-Qing;...

通讯作者：

Nie, Ya-Xiong;Liao, Duan-Fang

作者机构：

[Gu, Hong-Feng; Tang, Xiao-Qing; Tang, Ya-Ling] Univ South China, Dept Physiol, Hengyang, Peoples R China.

[Gu, Hong-Feng; Tang, Xiao-Qing; Tang, Ya-Ling] Univ South China, Inst Neurosci, Hengyang, Peoples R China.

[Li, Hai-Zhe; Nie, Ya-Xiong] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China.

[Xie, Xue-Jiao; Liao, Duan-Fang] Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

通讯机构：

[Nie, Ya-Xiong] U

[Liao, Duan-Fang] H

Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang, Peoples R China.

Hunan Univ Chinese Med, State Key Lab Chinese Med Powder & Med Innovat Hu, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

apoptosis;autophagy;cell damage;HT-22 cell;oxidized low-density lipoprotein

期刊：

CNS Neuroscience & Therapeutics

ISSN：

1755-5930

年：

2017

卷：

期：

页码：

341-349

DOI：

10.1111/cns.12680

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31371161, 81500349]; Basic Medicine Sciences in University of South China; Postdoctoral Science Foundation of ChinaChina Postdoctoral Science Foundation [2012M521525]

机构署名：

本校为通讯机构

院系归属：

药学院

摘要：

Aims: Although oxidized low-density lipoprotein (ox-LDL) in the brain induces neuronal death, the mechanism underlying the damage effects remains largely unknown. Given that the ultimate outcome of a cell is depended on the balance between autophagy and apoptosis, this study was performed to explore whether ox-LDL induced HT-22 neuronal cell damage via autophagy impairment and apoptosis enhancement. Methods: Flow cytometry and transmission electron microscopy (TEM) were used to evaluate changes in cell apoptosis and autophagy, respectively. The...

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Oxidized low-density lipoprotein induced mouse hippocampal HT-22 cell damage via promoting the shift from autophagy to apoptosis

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