Bioinformatics analysis on differentially expressed genes between colorectal adenoma and colorectal adenocarcinoma

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ding, Ning;Luo, Hongbiao;Peng, Tianshu;Zhang, Tao;Li, Menglei;...

通讯作者：

Yongheng He

作者机构：

[Deng, Yu; Ding, Ning; Li, Menglei; Zhang, Tao] Hunan Univ Chinese Med, Grad Sch, Changsha, Peoples R China.

[Luo, Hongbiao; He, Yongheng] Hunan Acad Tradit Chinese Med, Affiliated Hosp, Dept Anorectal Surg, Changsha, Peoples R China.

[Luo, Hongbiao] Chenzhou 1 Peoples Hosp, Dept Anorectal Surg, Chenzhou, Peoples R China.

[Luo, Hongbiao] Hunan Univ Chinese Med, Affiliated Hosp 2, Dept Anorectal Surg, Changsha, Peoples R China.

通讯机构：

[Yongheng He] D

Department of Anorectal Surgery, The Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine, Changsha, P.R. China

语种：

英文

关键词：

colorectal adenoma;colorectal adenocarcinoma;differentially expressed genes;progress;prognosis;immune infiltration

期刊：

Scottish Medical Journal

ISSN：

0036-9330

年：

2022

卷：

期：

页码：

369330221122306

DOI：

10.1177/00369330221122306

基金类别：

Natural Science Foundation of Hunan Province - Key Project of Hunan Administration of Traditional Chinese Medicine [2021JJ30419, 2021017]

机构署名：

本校为其他机构

院系归属：

第二中医临床医学院

研究生院

摘要：

BACKGROUND: Colorectal adenoma (CRA) is the main cause of the progression of Colorectal adenocarcinoma (COAD). Therefore, it is very important to accurately reveal its developmental mechanism. METHODS: Differential expression genes (DEGs) in three microarray datasets were screened using GEO and GEO2R. R packages were used for gene ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) path enrichment analysis. Hub genes screened by STRING, Cytoscape and CytoHubba were used. R was used for DEGs of hub genes, and Gene Expression Profiling Interactive Analysis (GEP...

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Bioinformatics analysis on differentially expressed genes between colorectal adenoma and colorectal adenocarcinoma

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