期刊论文

White Matter Diffusion Tensor Change After Long-Term Methamphetamine Abstaining Addicts Assessed by Tract Based Spatial Statistics

中文

中国医学影像学杂志

1005-5185

2020

28

5

321-326

10.3969/j.issn.1005-5185.2020.05.001

国家自然科学基金面上项目(61971451) 湖南省自然科学基金(2015JJ4081) 湖南省科技厅重点研发项目(2019SK2131)。

本校为其他机构

目的探讨甲基苯丙胺(MA)依赖者长期戒断后脑白质微观结构的改变。资料与方法对29例接受长期戒断的MA患者与31名正常对照进行全脑扩散张量成像扫描,采用基于纤维束示踪的空间统计(TBSS)方法,比较不同脑区各向异性分数(FA)值和平均扩散率(MD)值的差异,将异常脑区的FA值和MD值与认知功能测量进行相关分析。结果戒断组和对照组认知执行功能测试结果差异无统计学意义(P>0.05);与对照组比较,戒断组多个脑区FA值较低,多个脑区MD值较高(P

Purpose To investigate the changes of brain white matter microstructure in methamphetamine (MA) after a long-term withdrawal. Materials and Methods The whole-brain diffusion tensor imaging (DTI) scan was conducted to 29 patients with long-term MA withdrawal and 31 normal controls. Spatial statistics based on tract based spatial statistics (TBSS) was adopted, differences between fractional anisotropy (FA) and mean diffusivity (MD) values in different brain regions were compared, moreover, correlation between FA and MD values from the abnormal brain and cognitive function measurement was analyze...