A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

首页 > 成果 > 详情

认领

导出

Link by 中国知网学术期刊 Link by 万方学术期刊

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Guo, Shuai;Liu, Bei;Zhang, Mengjie;Li, Chunhui;Wang, Xiaoxia;...

通讯作者：

Huang, Yuanyu

作者机构：

[Zhang, Mengjie; Weng, Yuhua; Guo, Shuai; Huang, Yuanyu; Li, Chunhui] Beijing Inst Technol, Inst Engn Med, Key Lab Mol Med & Biotherapy, Sch Life Sci,Adv Res Inst Multidisciplinary Sci, Beijing 100081, Peoples R China.

[Liu, Bei; Li, Lele] CAS Ctr Excellence Nanosci, Natl Ctr Nanosci & Technol NCNST, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.

[Huang, Yuanyu] Hunan Univ Chinese Med, Sch Pharm, Changsha 410208, Peoples R China.

[Li, Lele] Univ Chinese Acad Sci, Coll Mat Sci & Optoelect Technol, Beijing 100049, Peoples R China.

[Weng, Yuhua] Hunan Univ Sci & Engn, Yongzhou 425199, Peoples R China.

通讯机构：

[Huang, Yuanyu] B

Beijing Inst Technol, Inst Engn Med, Key Lab Mol Med & Biotherapy, Sch Life Sci,Adv Res Inst Multidisciplinary Sci, Beijing 100081, Peoples R China.

语种：

英文

关键词：

FeOOH;siRNA delivery;RRM2;RNA interference;Polyetherimide;Cancer treatment

期刊：

中国化学快报：英文版

ISSN：

1001-8417

年：

2021

卷：

期：

页码：

102-106

DOI：

10.1016/j.cclet.2020.11.024

基金类别：

Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2018JJ1019, 2019JJ50196]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31871003, 31901053]; Beijing Institute of Technology Research Fund Program for Young Scholars [2018CX01023]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2018CX01023]; Beijing-Tianjin-Hebei Basic Research Cooperation Project [19JCZDJC64100]; Beijing Nova Program from Beijing Municipal Science & Technology Commission [Z201100006820005]; Young Elite Scientist Sponsorship Program of Beijing Association for Science and Technology (2020-2022); Hu-Xiang Young Talent Program [2018RS3094]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Despite the promising prospect of small interfering RNA（siRNA） for the treatment of diverse diseases,it remains challenging to develop novel delive ry materials to desired tissues and cells.In this study,a novel iron oxyhydroxide（FeOOH） nanoparticle（NP） whose surface was modified with branched polyetherimide（PEI） was developed to deliver siRNA into the cancer cells.It was demonstrated that PEI-FeOOH（PFeOOH） efficiently complexed siRNA,mediated effective cellular uptake and endosomal escape,thereby triggering robust gene silencing in v...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

A novel polyethyleneimine-decorated FeOOH nanoparticle for efficient siRNA delivery

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问