期刊论文

Liu, ZB;Liu, YF

英文

中国化学快报：英文版

1001-8417

2022

33

2

767-772

10.1016/j.cclet.2021.08.018

supported by the Huxiang Young Talent Program of Hunan Province （No. 2018RS3005）； the InnovationDriven Project of Central South University （No. 2020CX048）； the Changsha Science and Technology Plan Project （Nos. kq2005001, kq2004086）； the National Natural Science Foundation of China （No. 81301258）； the Natural Science Foundation of Hunan Province （Nos. 2019JJ60071, 2020JJ4680）； the Shenghua Yuying Project of Central South University,the Hunan Provincial Graduate Research and Innovation Project （No. CX20190242）； National College Students’ Innovation and Entrepreneurship Training Program （Nos. S2020105330414, S202010533015X, 8304180412）； the Postgraduate Innovation Project of Central South University （Nos. 2020zzts819, 2020zzts408, 2020zzts409, 2021zzts0977, 2021zzts0979）； the Open-End Fund for the Valuable and Precision Instruments of Central South University；

本校为其他机构

The drug resistance of chemotherapy is a major challenge to overcome for antineoplastic agents and the reverse of drug resistant is essential for cancer therapy. Herein, we developed a drug delivery system which can simultaneously detect/reverse the drug resistance and perform synergetic treatment of cancer. In this work, we integrated cyanine5（Cy5） modified mi RNA（let-7 i）（Cy5-mi RNA） and platinum onto nano-graphene oxide（NGO）（30-50 nm） platform to achieve simultaneously detection/reversion of drug resistance and synergetic treatment...