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LncRNA FLVCR1-AS1 mediates miR-23a-5p/SLC7A11 axis to promote malignant behavior of cervical cancer cells

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成果类型:
期刊论文
作者:
Zhou, Xi;Zhao, Xia;Wu, ZhouYi;Ma, Yan;Li, Heng
通讯作者:
Zhou, X
作者机构:
[Zhou, X; Zhou, Xi; Zhao, Xia; Ma, Yan] Univ South China Hengyang, Dept Gynecol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang City 421001, Hunan, Peoples R China.
[Wu, ZhouYi] Hunan Univ Chinese Med, Med Sch, Changsha, Hunan, Peoples R China.
[Li, Heng] Loudi Cent Hosp, Dept Gynecol, Loudi, Hunan, Peoples R China.
通讯机构:
[Zhou, X ] U
Univ South China Hengyang, Dept Gynecol, Affiliated Hosp 1, 69 Chuanshan Rd, Hengyang City 421001, Hunan, Peoples R China.
语种:
英文
关键词:
Cervical cancer;HeLa cells;FLVCR1-AS1;MicroRNA-23a-5p;solute carrier family 7 member 11
期刊:
Bioengineered
ISSN:
2165-5979
年:
2022
卷:
13
期:
4
页码:
10454-10466
基金类别:
The author(s) reported there is no funding associated with the work featured in this article.
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
Cervical cancer (CC) is the most common gynecological malignant tumor in the world. Long non-coding RNA (lncRNAs) plays an important role in cell activities of various cancers including CC. This study aims to reveal the biological function of FLVCR1-AS1 in CC and clarify its possible mechanism of action. The findings suggest that the expression of FLVCR1-AS1 was elevated in CC tissues and cell lines, and that high expression of FLVCR1-AS1 was associated with poor prognosis of CC patients. In addition, knockdown of FLVCR1-AS1 could inhibit the p...

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