期刊论文

Chen, Ze

英文

Frontiers in Immunology

1664-3224

2017

8

1070

10.3389/fimmu.2017.01070

This research was supported by the Cooperative Innovation Center of Engineering and New Products for Developmental Biology of Hunan Province (20134486), the Scientific Research Fund of Hunan Provincial Education Department (15K083), the Key project of Hunan province program in the field of social development (NO. 2015SK20331), the Teacher Research Fund of Central South University (2014JSJJ037), the Chinese State Key Project Specialized for Infectious Diseases (2013ZX10004003003), the National Key Subject of Drug Innovation (2013ZX09402302-007 and 2015ZX09101044), and the Shanghai Science and Technology Support Program, China (15431906500 and 16431904500).

本校为其他机构

The 2009 H1N1 influenza (Pdm09) pandemic has been referred to as the first influenza pandemic of the twenty-first century. There is a marked difference in antigenicity between the pandemic H1N1 virus and past seasonal H1N1 viruses, which allowed the pandemic virus to spread rapidly in humans. Antibodies (Abs) against hemagglutinin (HA), especially neutralizing Abs against epitopes in the head of HA, play critical roles in defending the host against the virus. Some preexisting neutralizing Abs that recognize neutralizing epitopes of Pdm09 HA, thereby affording cross-protection, have been report...