Connexin 43: A novel ginsenoside Rg1-sensitive target in a rat model of depression

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成果类型：

期刊论文

作者：

Xia, Cong-Yuan;Wang, Zhen-Zhen;Wang, Hui-Qin;Ren, Si-Yu;Lou, Yu-Xia;...

通讯作者：

Chen, Nai-Hong

作者机构：

[Wang, Zhen-Zhen; Lou, Yu-Xia; Jin, Can; Chen, Nai-Hong; Xia, Cong-Yuan; Chu, Shi-Feng] Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

[Wang, Zhen-Zhen; Lou, Yu-Xia; Jin, Can; Chen, Nai-Hong; Xia, Cong-Yuan; Chu, Shi-Feng] Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing 100050, Peoples R China.

[Wang, Zhen-Zhen] Yantai Univ, Key Lab Mol Pharmacol & Drug Evaluat, Minist Educ, Yantai 264005, Peoples R China.

[Ren, Si-Yu; Chen, Nai-Hong; Wang, Hui-Qin] Hunan Univ Chinese Med, Changsha 410208, Hunan, Peoples R China.

[Ren, Si-Yu; Chen, Nai-Hong; Wang, Hui-Qin] Hunan Engn Technol Ctr Standardizat & Funct Chine, Changsha 410208, Hunan, Peoples R China.

通讯机构：

[Chen, Nai-Hong] C

Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China.

Chinese Acad Med Sci & Peking Union Med Coll, Neurosci Ctr, Beijing 100050, Peoples R China.

语种：

英文

关键词：

Depression;Ginsenoside Rg1;Astrocyte;Gap junction;Connexin 43

期刊：

Neuropharmacology

ISSN：

0028-3908

年：

2020

卷：

170

期：

页码：

108041-

DOI：

10.1016/j.neuropharm.2020.108041

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81573636, 81773924, 81560663]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7182114]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [2018RC350010]; National Megaproject for Innovative Drugs [2018ZX09711001-002-007, 2018ZX09711001-003-005, 2018ZX09711001-009-013]; CAMS Innovation Fund for Medical Sciences (CIFMS) [2016-I2M-1-004]; Hunan Engineering Technology Center of Standardization and Function of Chinese Herbal Decoction Pieces [2016TP2008, BG201701]

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本校为其他机构

摘要：

Our previous studies have shown that ginsenoside Rg1 (Rg1) exerts antidepressant-like effects in animal models of depression, accompanied by an improvement of astrocytic gap junction functions. However, whether connexin 43 (Cx43), the major connexin forming gap junctions between astrocytes, is the key regulator of Rg1-induced antidepressant-like effects is still unknown. In this study, we examine in vitro and in vivo the involvement of Cx43 in the antidepressant effects of Rg1. Corticosterone was used to establish an in vitro rat model of depression. Treatment with Rg1 1 h prior to corticoster...

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Connexin 43: A novel ginsenoside Rg1-sensitive target in a rat model of depression

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