Prion-like propagation of α-synuclein in the gut-brain axis

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Chen, Ying;Shao, Qianhang;Yuan, Yu-He*;Chen, Nai-Hong*

通讯作者：

Yuan, Yu-He;Chen, Nai-Hong

作者机构：

[Shao, Qianhang; Chen, Ying; Chen, Nai-Hong; Yuan, Yu-He] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.

[Shao, Qianhang; Chen, Ying; Chen, Nai-Hong; Yuan, Yu-He] Chinese Acad Med Sci, Neurosci Ctr, Beijing 100050, Peoples R China.

[Shao, Qianhang; Chen, Ying; Chen, Nai-Hong; Yuan, Yu-He; Chen, NH] Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

[Chen, Nai-Hong] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Hunan, Peoples R China.

[Yuan, Yu-He; Chen, NH] Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 1 Xiannongtan St, Beijing 100050, Peoples R China.

通讯机构：

[Yuan, YH; Chen, NH] P

[Yuan, YH; Chen, NH] C

Peking Union Med Coll, 1 Xiannongtan St, Beijing 100050, Peoples R China.

Chinese Acad Med Sci, Inst Mat Med, Dept Pharmacol, 1 Xiannongtan St, Beijing 100050, Peoples R China.

语种：

英文

关键词：

alpha-synuclein;Prion-like;Enteric nervous system;Gut-brain axis;Non-motor symptom;Parkinson's disease

期刊：

Brain Research Bulletin

ISSN：

0361-9230

年：

2018

卷：

140

页码：

341-346

DOI：

10.1016/j.brainresbull.2018.06.002

基金类别：

Beijing Natural Science FoundationBeijing Natural Science Foundation [7161011]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81573640, 81773925, U1402221]

机构署名：

本校为其他机构

院系归属：

药学院

摘要：

Parkinson's disease (PD) is a progressive degenerative disease of the nervous system, which is characterized by movement disorders, such as static tremor, rigidity, and bradykinesia in advanced patients. Gastrointestinal (GI) dysfunction, such as gastric dysmotility, constipation, and anorectic dysfunction, is common non-motor symptom in the early stage of PD. The progression of PD includes the degenerative loss of dopaminergic (DA) neurons and aggregation of α-synuclein in the substantia nigra (SN). Interestingly, both of them are also presen...

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Prion-like propagation of α-synuclein in the gut-brain axis

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