Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination

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成果类型：

期刊论文

作者：

Xie, Mingxia;Long, Hongping;Tian, Sainan;Zhu, Zhengqing;Meng, Pan;...

通讯作者：

Wang, Hanqing;Peng, QH

作者机构：

[Peng, Qinghua; Zhu, Zhengqing; Wang, Hanqing; Wang, HQ; Xie, Mingxia; Tian, Sainan] Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha 410208, Peoples R China.

[Meng, Pan; Peng, Qinghua; Long, Hongping] Hunan Univ Chinese Med, Hosp 1, Ctr Med Res & Innovat, Changsha 410002, Peoples R China.

[Wang, Hanqing] Ningxia Med Univ, Coll Pharm, Yinchuan 750003, Peoples R China.

[Meng, Pan; Xie, Mingxia; Guo, Dongwei] Hunan Univ Chinese Med, Coll Chinese Med, Changsha 410208, Peoples R China.

[Du, Ke; Wang, Yajing] Hunan Univ Chinese Med, Coll Pharm, Changsha 410208, Peoples R China.

通讯机构：

[Peng, QH ; Wang, HQ] H

Hunan Univ Chinese Med, Coll Tradit Chinese Med, Changsha 410208, Peoples R China.

语种：

英文

关键词：

Depression;Dry eye disease;Polyubiquitination;Saikosaponin F;TAK1;TRIM8

期刊：

International Immunopharmacology

ISSN：

1567-5769

年：

2024

卷：

130

页码：

111749

DOI：

10.1016/j.intimp.2024.111749

基金类别：

National Natural Science Foundation Program [82305037, 81574031]; Key research and development projects of Ningxia [2021BEG02040]; Key Projects of Hunan Provincial Department of Education [22A0259, 21A0238]; Open Fund Project of State Key Laboratory Cultivation Base Jointly Constructed by Ministry and Province [2022FTKFJJ09]; Hunan Province Clinical Medical Technology Innovation Guidance Project [2021SK50809]; The 2021 "Academician Liu Liang Workstation" Guidance Project [21YS002]; Hunan Province Graduate Research Innovation Project [CX20210679/20210708/20210705, CX20220774/20220780/20220812]

机构署名：

本校为第一且通讯机构

院系归属：

中医学院

第一中医临床学院

药学院

摘要：

AIMS: Saikosaponin F (SsF) is one of the major active ingredients of Radix Bupleuri, an herb widely used in the treatment of depression. Studies have shown that dry eye disease often occurs together with depression. The aim of this study is to investigate whether SsF can improve depression-associated dry eye disease and explore the underlying mechanism. METHODS: Behavioral test was used to verify the effect of SsF on CUMS-induced depression-like behaviors in mice. Corneal fluorescein staining, phenol red cotton thread test and periodic acid-Sch...

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Saikosaponin F ameliorates depression-associated dry eye disease by inhibiting TRIM8-induced TAK1 ubiquitination

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