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Inflammatory cytokines mediating the effect of oral lichen planus on oral cavity cancer risk: a univariable and multivariable mendelian randomization study

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成果类型:
期刊论文
作者:
Tao Zheng;Chengyong Liu;Yetong Wang;Han Zhou;Rong Zhou;...
通讯作者:
Keke Zhu
作者机构:
[Zibing Zhu; Yisi Tan; Jin Tan; Keke Zhu] Department of Stomatology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China
[Chengyong Liu; Yetong Wang; Han Zhou; Xuan Zhu] Hunan University of Traditional Chinese Medicine, Changsha, China
[Rong Zhou] Changsha Hospital for Maternal and Child Health Care, Changsha, China
[Zhengrui Li] College of Stomatology, Shanghai Jiao Tong University, Shanghai, China
[Xufeng Huang] Faculty of Dentistry, University of Debrecen, Debrecen, Hungary
通讯机构:
[Keke Zhu] D
Department of Stomatology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha, China
语种:
英文
关键词:
Oral lichen planus;Oral cavity cancer;Mendelian randomisation;Inflammatory cytokines;Causal inference
期刊:
BMC Oral Health
ISSN:
1472-6831
年:
2024
卷:
24
期:
1
页码:
1-10
基金类别:
The General Program of National Natural Science Foundation (NSFC82374530); Research Project supported by Hunan Provincial Administration of Traditional Chinese Medicine (2021240); Research Project supported by Hunan Provincial Department of Education (22C0190); 712 Talent Project supported by Changsha Maternal and Child Health Hospital (20211159).
机构署名:
本校为通讯机构
院系归属:
医学院
摘要:
While observational studies and experimental data suggest a link between oral lichen planus (OLP) and oral cavity cancer (OCC), the causal relationship and the role of inflammatory cytokines remain unclear. This study employed a univariable and multivariable Mendelian Randomization (MR) analysis to investigate the causal relationship between OLP and the risk of OCC. Additionally, the potential role of inflammatory cytokines in modulating this association was explored. Instrumental variables were derived from genetic variants associated with OLP...

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