Purpose: To study the combined effects of tenofovir and interferon alpha 1b on viral load and peripheral blood regulatory T cell concentrations of chronic hepatitis B (CHB) subjects. Methods: Patients with chronic hepatitis B (86 cases) were randomly assigned to two groups: control group and study group. In control subjects, tenofovir was given orally (300 mg/kg bwt/day). In addition to tenofovir, the study group received interferon alpha 1b injection intramuscularly at a dose of 50 mu g/kg thrice a week. Liver function, serum hepatitis B viral (HBV) load, and serum levels of peripheral blood ...
