Systematic Pharmacological Strategies to Explore the Regulatory Mechanism of Ma Xing Shi Gan Decoction on COVID-19

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成果类型：

期刊论文

作者：

张世鹰;李玲;张宁;夏洪涛;卢芳国;...

通讯作者：

Fang-Guo, L.;Wei-Qing, L.

作者机构：

[Fang-Guo L.; 李玲] Hunan University of Chinese Medicine, Changsha, Hunan 410208, China

Department of Traditional Chinese Medicine, Shenzhen Luohu People's Hospital, Shenzhen, Guangdong 518001, China

Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518001, China

Department of Respiratory Disease, Shenzhen Luohu People's Hospital, Shenzhen, Guangdong 518001, China

Department of Respiratory Disease, The Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong 518001, China

通讯机构：

[Fang-Guo, L.] H

[Wei-Qing, L.] D

Department of Traditional Chinese Medicine, Shenzhen Luohu People’s Hospital, Shenzhen, Guangdong, 518001, China<&wdkj&>Department of Traditional Chinese Medicine, The Third Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong, 518001, China<&wdkj&>Hunan University of Chinese Medicine, Changsha, Hunan, 410208, China

语种：

英文

关键词：

ACE2 receptor;Coronavirus disease 2019 (COVID-19);Ma Xing Shi Gan Decoction (MXSGD);Mechanism;Network pharmacology

关键词(中文)：

新型冠状病毒肺炎;麻杏石甘汤;网络药理学;作用机制;ACE2受体

期刊：

数字中医药(英文)

ISSN：

2096-479X

年：

2020

卷：

期：

页码：

96-115

DOI：

10.1016/j.dcmed.2020.06.004

基金类别：

We thank for the funding support from the National Natural Science Foundation of China (No. 81774126 and No. 81973670), the Natural Science Foundation of Hunan Province (No. 2016JJ2095 and No. 2017JJ3232), Scientific Research Project of Traditional Chinese Medicine for the Prevention and Treatment of New Pneumonia in Hunan Province (No. GYGG007), the Construction Project of Specialty of Traditional Chinese Medicine in Guangdong Province, and the Construction Project of Specialty of Traditional Chinese Medicine in Shenzhen.

机构署名：

本校为第一且通讯机构

摘要：

Objective: To use systematic pharmacological strategies to explore the regulatory mechanisms of Ma Xing Shi Gan Decoction (MXSGD) against the coronavirus disease 2019 (COVID-19). Methods: Data on the compounds and targets of MXSGD were collected from the Traditional Chinese Medicene Systems Parmacology Database and Analysis Platform (TCMSP) and TCM Databases@Taiwan. Data on ACE2-related targets and the protein-protein interaction (PPI) were collected from the String database. The Cytoscape 3.7.2 was used to construct and analyze the networks. T...

摘要(中文)：

目的探析麻杏石甘汤（MXSGD）干预新型冠状病毒肺炎（COVID-19）的作用机制。方法基于药代动力学参数通过TCMSP数据库、TCM Database@Taiwan数据库筛选MXSGD的成药性活性成分及其调控的蛋白靶标,随后通过String数据库获得新型冠状病毒转染宿主的（COVID-19）ACE2受体及与之相互作用的相关靶点,利用Cytoscape 3.7.2构建相关网络并进行网络拓扑学分析,对网络中的核心靶点通过DAVID数据库进行基因本体（GO）富集分析和信号通路富集分析。结果共收集到272个MXSGD靶点和21个新型冠状病毒（SARS-Co V-2）肺炎的潜在靶点。在此基础上,构建并分析了4个网络:（1）MXSGD成分-靶点网络;（2）MXSGD-SARS-Co ...

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