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Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells

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成果类型:
期刊论文
作者:
Liao, Peng*;Liao, Meifang;Li, Ling(李玲);Tan, Bie;Yin, Yulong
通讯作者:
Liao, Peng
作者机构:
[Tan, Bie; Yin, Yulong; Liao, Peng] Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, 644 Yuandaer Rd, Changsha 410125, Hunan, Peoples R China.
[Li, Ling; Liao, Meifang] Hunan Univ Chinese Med, Coll Tradit Chinese Med, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.
通讯机构:
[Liao, Peng] C
Chinese Acad Sci, Key Lab Agroecol Proc Subtrop Reg, Inst Subtrop Agr, 644 Yuandaer Rd, Changsha 410125, Hunan, Peoples R China.
语种:
英文
期刊:
Toxicology Research
ISSN:
2045-452X
年:
2017
卷:
6
期:
6
页码:
866-877
基金类别:
National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31402088]; ISA, CAS (QNCXTD_TBE)
机构署名:
本校为其他机构
院系归属:
中医学院
摘要:
This study was conducted to determine the effect of 200 ng mL−1 and 2000 ng mL−1 deoxynivalenol (DON) on apoptosis, barrier function, nutrient transporter gene expression, and free amino acid variation as well as on mitochondrial biogenesis and function-related gene expression in the intestinal porcine epithelial cell line J2 (IPEC-J2) for 6 h, 12 h, and 24 h. Exposure to 200 ng mL−1 DON inhibited the cell viability and promoted cell cycle progression from the G2/M phase to the S phase (P < 0.05). The data showed that the IPEC-J2 cell conten...

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