Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia

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成果类型：

期刊论文

作者：

Li, Cunyan;Tao, Huai（陶怀）;Yang, Xiudeng;Zhang, Xianghui;Liu, Yong;...

通讯作者：

Tang, Yamei

作者机构：

[Li, Cunyan] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Lab Med, Affiliated Hosp 1, Changsha 410005, Hunan, Peoples R China.

[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.

[Yang, Xiudeng; Tang, Aiguo; Tang, Yamei] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.

[Zhang, Xianghui; Liu, Yong] Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.

[Zhang, Xianghui; Liu, Yong] Cent S Univ, Mental Hlth Inst, Changsha, Hunan, Peoples R China.

通讯机构：

[Tang, Yamei] C

Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.

语种：

英文

关键词：

BDNF;DNMT1;ErbB4;NRG1;Schizophrenia;TET1;biomarker

期刊：

International Journal of Medical Sciences

ISSN：

1449-1907

年：

2018

卷：

期：

页码：

900-906

DOI：

10.7150/ijms.24346

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81771448, 81503276]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [2015JJ4069]

机构署名：

本校为其他机构

院系归属：

医学院

中医学院

摘要：

Schizophrenia (SZ) is a devastating psychiatric disorder. Validation of potential serum biomarkers during first-episode psychosis (FEP) is especially helpful to understand the onset and prognosis of this disorder. To address this question, we examined multiple blood biomarkers and assessed the efficacy to diagnose SZ. The expression levels of Neuregulin1 (NRG1), ErbB4, brain-derived neurotrophic factor (BDNF), DNA methyltransferases 1 (DNMT1) and ten-eleven translocation 1 (TET1) proteins in peripheral blood of 53 FEP patients and 57 healthy co...

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Assessment of a combination of Serum Proteins as potential biomarkers to clinically predict Schizophrenia

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