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Assessment of a combination of serum proteins as potential biomarkers to clinically predict schizophrenia

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成果类型:
期刊论文
作者:
Li, Cunyan;Tao, Huai(陶怀);Yang, Xiudeng;Zhang, Xianghui;Liu, Yong;...
通讯作者:
Tang, YM
作者机构:
[Li, Cunyan] Hunan Normal Univ, Hunan Prov Peoples Hosp, Dept Lab Med, Affiliated Hosp 1, Changsha 410005, Hunan, Peoples R China.
[Tao, Huai] Hunan Univ Chinese Med, Dept Biochem & Mol Biol, Changsha 410208, Hunan, Peoples R China.
[Tang, Yamei; Yang, Xiudeng; Tang, Aiguo] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.
[Zhang, Xianghui; Liu, Yong] Cent S Univ, Xiangya Hosp 2, Dept Psychiat, Changsha 410011, Hunan, Peoples R China.
[Zhang, Xianghui; Liu, Yong] Cent S Univ, Mental Hlth Inst, Changsha, Hunan, Peoples R China.
通讯机构:
[Tang, YM ] C
Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.
语种:
英文
关键词:
biological marker;brain derived neurotrophic factor;DNA (cytosine 5) methyltransferase 1;epidermal growth factor receptor 4;neu differentiation factor;ten eleven translocation 1 protein;unclassified drug;biological marker;brain derived neurotrophic factor;epidermal growth factor receptor 4;ERBB4 protein, human;mixed function oxidase;oncoprotein;plasma protein;TET1 protein, human;adolescent;adult;Article;concentration (parameters);controlled study;diagnostic accuracy;diagnostic test accuracy study;disease course;enzyme linked immunosorbent assay;female;human;human cell;intermethod comparison;major clinical study;male;multivariate logistic regression analysis;peripheral circulation;predictive value;predictor variable;protein analysis;protein blood level;protein expression level;psychosis;receiver operating characteristic;schizophrenia;blood;case control study;schizophrenia;statistical model;young adult;Adolescent;Adult;Biomarkers;Blood Proteins;Brain-Derived Neurotrophic Factor;Case-Control Studies;Enzyme-Linked Immunosorbent Assay;Female;Humans;Logistic Models;Male;Mixed Function Oxygenases;Proto-Oncogene Proteins;Receptor, ErbB-4;Schizophrenia;Young Adult
期刊:
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
ISSN:
1449-1907
年:
2018
卷:
15
期:
9
页码:
900-906
基金类别:
This work was supported by the National Natural Science Foundation of China (No. 81771448, No. 81503276) and the Hunan Provincial Natural Science Foundation of China (No. 2015JJ4069).
机构署名:
本校为其他机构
院系归属:
医学院
中医学院
摘要:
Schizophrenia (SZ) is a devastating psychiatric disorder. Validation of potential serum biomarkers during first-episode psychosis (FEP) is especially helpful to understand the onset and prognosis of this disorder. To address this question, we examined multiple blood biomarkers and assessed the efficacy to diagnose SZ. The expression levels of Neuregulin1 (NRG1), ErbB4, brain-derived neurotrophic factor (BDNF), DNA methyltransferases 1 (DNMT1) and ten-eleven translocation 1 (TET1) proteins in peripheral blood of 53 FEP patients and 57 healthy co...

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