期刊论文

Preliminary Study on the Effect of Autoimmune Disease Serum on the Release Function and Free Radicals of Cultured Human Umbilical cord Vein Endothelial Cell

中文

血栓与止血学

1009-6213

1994

02

52-55+96

本校为第一机构

用自身免疫病血清作用于培养的人脐静内皮细胞,观察其部分释放反应及自由基变化。结果显示,与小牛血清组比较,自身免疫病全血清组条件液中6-keto-PGF1α含量及细胞液中GSH—Px活性显著升高（P【0.05.P【0.01）;自身免疫病灭活补体血清组条件液中TxB2含量及细胞液中GSH—Px活性升高明显（P【0.05）;而细胞液中SOD活性6-keto-PGF1α含量无明显变化（P】0.05）,MDA含量虽呈升高趋势,但无统计学意义（P】0.05）。各组细胞形态在光学显微镜下均未见明显改变。提示,免疫反应及脂质过氧化反应可能参与了对血管内皮细胞的影响。

The part release function and free radical (FR) changes of cultured human umbilical cord vein endothelial cell stimulated with autoimmune disease (AID) serum were observed. The results showed that CM-6-kete-PGF1α contents in AID group CM-TXB2 contents in AID' group and GSH-Px activities in AID and AID' groups significantly increased (P0. 05) . The morphological changes HUVEC in four groups had not been proved. All above suggested that immune reaction and lipid peroxide reaction might participate in the function changes of VEC.