期刊论文

中文

中西医结合肝病杂志

1005-0264

2012

22

4

231-233

10.3969/j.issn.1005-0264.2012.04.015

湖南省普通高等学校青年骨干教师培养基金(No.2010)；

本校为第一机构

目的:动态观察温阳解毒化瘀方对肝衰竭大鼠内毒素血症(ITEM)的影响.方法:将85只SD大鼠随机分为正常组、模型组、对照组(予乳果糖+三联活菌溶液)及温阳解毒化瘀颗粒组(实验组),采用D-半乳糖胺(D-gal)腹腔注射致肝衰竭ITEM大鼠模型.正常组在腹腔注射生理盐水12小时后处死,其余各组分别于造模后12小时、24小时各取10只大鼠处死,检测各组大鼠血清转氨酶( ALT、AST)、肝组织病理学、门静脉及结肠内毒素水平.结果:模型组12小时时ALT和AST较正常组升高(P＜0.05),24小时时门静脉及结肠内毒素水平明显升高(P＜0.01),肝组织大面积坏死；实验组及对照组在造模后12小时各观察指标与模型组比较,差异无显著性意...

Objective：To observe the effect of Wenyang Jiedu Huayu prescription on intestinal endotoxemia（ITEM） in rat with hepatic failure dynamically.Methods：Eighty and five rats were randomly divided into 4 groups： normal group,model group,control group,Wenyang Jiedu Huayu group（experimental group）.The rat model of hepatic failure ITEM was established by intraperitoneal injection of D-galactosamine（D-gal）.The rats of normal group were put to death 12 hours later after intraperitoneal injection,of normal saline.The other rats of from the rest ea...